Immunotherapy for Lymphoma Using T Cells Targeting Multiple Tumor-Associated Antigens

Tumor-Associated Antigens for Specific Immunotherapy of Prostate Cancer

Prostate cancer (PCa) is the most common noncutaneous cancer diagnosis and the second leading cause of cancer-related deaths among men in the United States. Effective treatment modalities for advanced metastatic PCa are limited. Immunotherapeutic strategies based on T cells and antibodies represent interesting approaches to prevent progression from localized to advanced PCa and to improve survi...

Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.

Monoclonal antibody (mAb) therapy against tumor antigens expressed on the tumor surface is associated with clinical benefit. However, many tumor antigens are intracellular molecules that generally would not be considered suitable targets for mAb therapy. In this study, we provide evidence challenging this view through an investigation of the efficacy of mAb directed against NY-ESO-1, a widely e...

Targeting cytomegalovirus (CMV) antigens for GBM immunotherapy

Despite aggressive and incapacitating conventional therapy, glioblastoma multiforme (GBM) remains uniformly lethal. Immunotherapy in which the immune system (particularly cellular effectors such as T cells) is harnessed to specifically attack malignant cells offers a treatment option with less toxicity. The presence of CMV antigens in GBM, and not in normal brain tissue presents a unique opport...

Targeting the right regulatory T-cell population for tumor immunotherapy

Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25(low) cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-medi...

Targeting of Tumor Cells for Human T Cells by Nonpeptide Antigens